A Pyrazole Derivative, YM-58483, Potently
نویسندگان
چکیده
منابع مشابه
A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.
3,5-Bis(trifluoromethyl)pyrazole derivative (BTP2) or N-[4-3, 5-bis(trifluromethyl)pyrazol-1-yl]-4-methyl-1,2,3-thiadiazole-5-carboxamide (YM-58483) is an immunosuppressive compound that potently inhibits both Ca2+ influx and interleukin-2 (IL-2) production in lymphocytes. We report here that BTP2 dosedependently enhances transient receptor potential melastatin 4 (TRPM4), a Ca2+-activated nonse...
متن کاملA Pyrazole Derivative Potently Inhibits Lymphocyte Ca Influx and Cytokine Production by Facilitating Transient Receptor Potential Melastatin 4 Channel Activity
3,5-Bis(trifluoromethyl)pyrazole derivative (BTP2) or N-[4–3, 5-bis(trifluromethyl)pyrazol-1-yl]-4-methyl-1,2,3-thiadiazole-5carboxamide (YM-58483) is an immunosuppressive compound that potently inhibits both Ca influx and interleukin-2 (IL-2) production in lymphocytes. We report here that BTP2 dosedependently enhances transient receptor potential melastatin 4 (TRPM4), a Ca -activated nonselect...
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تاریخ انتشار 2003